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目的 评估自动调节持续气道正压通气 ( auto-CPAP)治疗阻塞性睡眠呼吸暂停 ( OSA)的疗效。方法 研究 2 8例 OSA患者用 auto-CPAP治疗前、治疗时的临床症状和睡眠多导图各参数的变化。结果 治疗后次日有 96.3 %的患者白日困倦消除 ,80 %口干症状减轻 ,83 .3 %晨起头痛缓解 ( P<0 .0 0 1 )。最长呼吸暂停时间减少 (治疗前 53 .5± 3 2 .5秒 ,治疗时 2 6.9± 1 8.2秒 ,P<0 .0 0 1 ) ;平均呼吸暂停时间由 2 0 .6± 7.1秒降至 1 4.7± 6.6秒 ( P<0 .0 0 1 ) ;呼吸紊乱指数 ( AHI)由 3 6.6± 2 5.0次降至 6.2± 6.2次 ( P<0 .0 0 1 ) ;最低 SO2 %有明显改善 (治疗前75.1± 1 1 .2 ,治疗时 87.2± 3 .2 ,P<0 .0 0 1 )。另外 ,治疗时 I期睡眠减少 ( P<0 .0 1 ) , + 期睡眠明显增加 ( P<0 .0 0 1 )以及及醒觉指数、醒觉时间均有所下降 ( P<0 .0 5)。结论 auto-CPAP是一安全、有效、无创治疗 OSA的手段 ,其不仅改善了 OSA的 AHI、最低 SO2 % ,还改善了睡眠结构。
Objective To evaluate the efficacy of auto-adjusting continuous auto-CPAP in the treatment of obstructive sleep apnea (OSA). Methods 28 patients with OSA patients with auto-CPAP before treatment and treatment of clinical symptoms and polysomnography changes in sleep parameters. Results The day after treatment, 96.3% of the patients were relieved of daytime drowsiness, 80% of dry mouth symptoms and 83.3% of morning headache relieves (P <0.01). The longest duration of apnea was reduced (53.5 ± 32.5 seconds before treatment, 6.92 ± 8.2 seconds at treatment, P <0.01); mean apnea duration decreased from 20.6 ± 7.1 seconds To 4.7 ± 6.6 seconds (P0.01). The respiratory disturbance index (AHI) decreased from 3.66 ± 5.0 to 6.2 ± 6.2 (P0.01), and the lowest SO2% was significantly (75.1 ± 11.2 before treatment, 87.2 ± 3.2 at treatment, P <0.01). In addition, the number of sleep in stage I decreased (P <0.01), the stage + sleep increased significantly (P <0.01) and the index of awakening and awakening decreased (P <0. 0) 5). Conclusion Auto-CPAP is a safe, effective and noninvasive means of treating OSA. It not only improves AHI of OSA but also lowest SO2%, and also improves sleep structure.