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目的比较新旧工艺制备的蛭龙活血通瘀胶囊的活血化瘀作用。方法 90只SD大鼠随机分为假手术组,模型组,蛭龙活血通瘀胶囊新、旧工艺高、中、低剂量组及步长脑心通组,线栓法制备局灶性脑缺血大鼠模型,比较各组用药后的血液流变学指标;80只SD大鼠随机分为正常组、蛭龙活血通瘀胶囊新、旧工艺高、中、低剂量组及步长脑心通组,比较用药后肠系膜微循环和凝血功能。结果与模型组相比,蛭龙活血通瘀胶囊新、旧工艺高剂量组的血浆粘度、红细胞聚集指数均降低,有显著性差异(P<0.05)。新、旧工艺高剂量组能够升高正常大鼠肠系膜微循环Flux(血流量)和Speed(血流速度),有显著性差异(P<0.05)。新、旧工艺对正常大鼠血浆PT、APTT未见明显影响(P>0.05)。结论蛭龙活血通瘀胶囊新、旧制备工艺均能有效改善局灶性脑缺血大鼠的血液流变学指标,对正常大鼠肠系膜微循环具有促进作用,不影响凝血功能。新工艺制备方法可用于蛭龙活血通瘀胶囊的制剂制备。
OBJECTIVE To compare the blood-activating and blood-stasis-removing effect of Zhuxuhuoxuetongyu Capsule prepared by new and old technology. Methods Ninety Sprague Dawley rats were randomly divided into three groups: sham-operation group, model group, new-aged and old-aged high, medium and low dose of Zhi Long Huoxue Tongyu Capsule, 80 SD rats were randomly divided into normal group, the new Longzhihuoxuetongyu capsule, the old, the old high, medium and low dose group and step brain center Tong group, comparing the mesenteric microcirculation and coagulation function. Results Compared with the model group, the plasma viscosity and erythrocyte aggregation index of the new and old high-dose group treated with Zhudilong Huoxuetongyu Capsule decreased, with significant difference (P <0.05). New and old high-dose group can raise the Flux (blood flow) and Speed (velocity) of mesenteric microcirculation in normal rats significantly (P <0.05). New and old technology had no obvious effect on the plasma PT and APTT in normal rats (P> 0.05). Conclusion Both the new and old preparations of Zhi Long Huoxue Tongyu Capsule can effectively improve the hemorheological parameters in focal cerebral ischemia rats and promote the mesenteric microcirculation in normal rats without affecting the coagulation function. The preparation method of the new process can be used for preparation of preparation of preparation of the preparation of the preparation of the preparation of the preparation of the capsule of Hirudo Huoxue Tongyu.