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局部贫血心肌的保护性治疗计划,其目的是维持细胞的生命,赢得时间,直到侧枝循环的发展,栓塞溶解或者是以手术达到血流恢复为止。这种抢救局部贫血心肌的任一治疗的成功可能,是取决于治疗开始时局部贫血细胞仍然是可逆转性的损伤,并且靠足够的局部组织灌注,允许有适当量的药物流至受损伤处。这两种情况在发展着的心肌梗塞边缘是常碰到。并且抢救心肌细胞的相应量将是取决于靠局部贫血的时间、梗塞血管大小,和预先即有适当量的侧枝循环。对于发展保护性药的最有逻辑的方法是了解在局部贫血中不可逆转的细胞损伤的发病机理。有许多方案用在实验动物或临床上是成功的,并且推测机理是改善有关局部细胞需要的能量供应,或者是直接稳定细胞代谢和细胞的生物结构。已证明在狗的冠状动脉闭索后心得安有减慢局部贫血细胞损伤的能力,并且对改变不可逆转的损伤发展中的机理研究,考虑它是一种保护性药物。心得安有好几种药理作用,它的延迟局部贫血损伤的机理尚待研究。
The plan of protective treatment of the local anemic myocardium is to maintain the life of the cell and to gain time until the development of the collateral circulation, the dissolution of the embolus or the surgical recovery of blood flow. The success of any treatment for this rescue of the anemic myocardium depends on the fact that local anemic cells are still reversible at the start of treatment and are perfused with sufficient topical tissue to allow the proper amount of drug to flow to the site of injury . These two conditions are often encountered on the verge of developing myocardial infarction. And the corresponding amount of rescue myocardial cells will be dependent on the time by the local anemia, the infarct size, and the appropriate amount of collateral circulation in advance. The most logical way to develop protective drugs is to understand the pathogenesis of irreversible cellular damage in local anemia. There are many protocols that have been used successfully in experimental animals or clinics and speculated that the mechanism is to improve the energy supply required by local cells or to directly stabilize cell metabolism and cell biological structures. It has been demonstrated that dogs have the ability to slow down the damage of anemia cells after coronary occlusion of the dog, and that it is a protective drug that can be used to change the mechanism of irreversible injury development. There are several pharmacological effects of peace of mind, its mechanism of delayed local anemia remains to be studied.