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目的探讨血清纤维蛋白原(Fg)与超氧化物歧化酶(SOD)在糖尿病周围神经病变(DPN)中的临床价值。方法入选对象为确诊DPN(A组)48例、亚临床DPN(B组)40例,另选取无DPN的2型糖尿病患者(C组)42例及正常对照组(D组)35例,分别测定其血清Fg、SOD水平。结果 Fg水平在4组中比较差异有统计学意义(P<0.01),且随DPN进展有递升趋势;SOD水平在4组中比较有统计学差异(P<0.01),且随DPN进展有递降趋势。相关分析显示,Fg与SOD水平呈负相关(r=-0.409,P<0.01)。结论随着DPN的进展,血清Fg水平渐升高、而SOD水平渐下降,提示微循环障碍与氧化应激可能参与DPN的发生、发展,且二者间存在一定关联。
Objective To investigate the clinical value of serum fibrinogen (Fg) and superoxide dismutase (SOD) in diabetic peripheral neuropathy (DPN). Methods Forty-eight patients with confirmed DPN (group A), 40 patients with subclinical DPN (group B), 42 patients with type-2 diabetes without DPN (group C) and 35 patients with normal control group (group D) Determination of serum Fg, SOD levels. Results There was a significant difference in Fg levels between the four groups (P <0.01), and there was an increasing trend with the progression of DPN. The levels of SOD in the four groups were statistically different (P <0.01), and decreased with the progress of DPN trend. Correlation analysis showed that Fg was negatively correlated with SOD level (r = -0.409, P <0.01). Conclusions With the progress of DPN, serum Fg level gradually increases and SOD level gradually decreases, suggesting that microcirculation disturbance and oxidative stress may be involved in the occurrence and development of DPN, and there is a certain correlation between them.