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对人体外淋巴细胞用不同浓度的甲基氯化汞（ＭＭＣ）和氯化汞（ＭＣ）处理１ｈ，观察ＤＮＡ损伤的程度，采用细胞琼脂糖凝胶电泳技术（ＳＣＧＥ）进行比较研究。这两种汞化物均不同程度的显示了剂量反应关系。ＤＮＡ损伤的程度从１０－５ｍｏｌ／Ｌ起与空白对照相比，呈现有意义的增加，细胞ＤＮＡ断裂频率的增加与毒性呈现为线性增长的关系。剂量愈高，则ＤＮＡ的彗尾链愈长，两种化合物在同样的实验条件下显示了相似的分裂剂的潜能，氯化汞表现出的遗传毒性更明显
Human peripheral blood lymphocytes were treated with various concentrations of methylmercuric chloride (MMC) and mercuric chloride (MC) for 1 h. The extent of DNA damage was observed and compared by cell agarose gel electrophoresis (SCGE). Both of these two mercury compounds show different degrees of dose-response relationship. The degree of DNA damage showed a significant increase from 10-5mol / L compared with the blank control, and the increase of the frequency of DNA DNA breakage and the linear increase of toxicity showed. The higher the dose, the longer the DNA’s comet-tail chain. Both compounds showed similar potential for cleavage under the same experimental conditions, and the mercury chloride showed more pronounced genotoxicity