人类妊娠早期的胚胎发育是在一个相对缺氧的微环境中进行的,缺氧诱导因子(Hypoxia inducible factor,HIF)-1α是研究最多也是最主要的在缺氧环境下调节氧代谢平衡的因子,通过影响胚胎血管生成、缺氧环境下的能量代谢及滋养层细胞功能等来调节早期妊娠的胚胎生长,故其表达水平的高低直接影响着胚胎的生长发育。1HIF-1α的结构和活性调节:HIF-1由120KD的α亚单 Hypoxia inducible factor (HIF) -1α is the most frequently studied and most important factor that regulates the metabolism of oxygen metabolism in hypoxia environment in early stage of human embryo development in a relatively hypoxic microenvironment. , Through regulating embryo angiogenesis, hypoxia energy metabolism and trophoblastic cell function to regulate embryo growth in early pregnancy, so the level of its expression directly affects the growth and development of the embryo. Structure and activity regulation of 1HIF-1α: HIF-1 consists of α-subunit of 120 kD