返流性食管炎系指胃或十二指肠液返流入食管内所引起的炎症性病变,多发于中年或老年人,本病有慢性化倾向,少数可致食管狭窄或形成Barrett’s上皮,后者被认为是癌前期化生上皮。近10年来国外有关本病的病理生理及临床研究资料较多,发病机制与以下几点有关:①抗返流屏障功能异常,主要归 Reflux esophagitis refers to the stomach or duodenal fluid reflux into the esophagus caused by inflammatory lesions, mainly in middle-aged or elderly, the disease has a tendency to chronic, a small number can cause esophageal stenosis or the formation of Barrett’s epithelium, after It is considered as precancerous metaplasia. In the past 10 years, there are more information about the pathophysiology and clinical research about this disease abroad. The pathogenesis is related to the following points: ① The anti-reflux barrier dysfunction mainly belongs to