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目的:探讨肺血栓栓塞症(PTE)患者血清高敏C反应蛋白(hs-CRP)与血浆凝血因子Ⅶ(FⅦ)活性的关系。方法:选择103例PTE患者(PTE组)及61例健康人(正常对照组)进行hs-CRP及FⅦ活性的测定,hs-CRP、FⅦa、FⅦag采用酶联免疫吸附试验法(ELISA),FⅦc采用一期血凝法测定。结果:与正常对照组相比,PTE组患者hs-CRP[(19.25±7.65)mg/L:(29.59±11.77)mg/L,P<0.01]、FⅦa[(71.27±26.83):(209.80±87.89),P<0.01]、FⅦag[(75.12±19.35):(96.11±21.68),P<0.05]水平均显著升高。相关分析显示,FⅦa、FⅦag与hs-CRP呈正相关(r=0.982,P<0.01),FⅦc与hs-CRP无明显相关性(r=0.18,P>0.05)。结论:肺血栓栓塞症患者高敏C反应蛋白水平显著升高,出现外源性凝血途径的激活,FⅦa是肺血栓栓塞发病的危险因素,可能较FⅦc或FⅦag更敏感。
Objective: To investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP) and plasma coagulation factor Ⅶ (FⅦ) in patients with pulmonary thromboembolism (PTE). Methods: The hs-CRP and FⅦ activities of 103 PTE patients (PTE group) and 61 healthy volunteers (normal control group) were determined. The expressions of hs-CRP, FⅦa and FⅦag were detected by enzyme-linked immunosorbent assay Using a hemagglutination test. Results: Compared with the control group, the levels of hs-CRP in the PTE group were significantly higher than those in the normal control group (19.25 ± 7.65 mg / L vs 29.59 ± 11.77 mg / L, P <0.01, FⅦa [(71.27 ± 26.83) 87.89), P <0.01], FⅦag [(75.12 ± 19.35) :( 96.11 ± 21.68), P <0.05]. Correlation analysis showed that there was a positive correlation between FⅦa and FⅦag and hs-CRP (r = 0.982, P <0.01). There was no significant correlation between FⅦc and hs-CRP (r = 0.18, P> 0.05). CONCLUSIONS: Patients with pulmonary thromboembolism have significantly increased levels of high-sensitivity C-reactive protein and activation of extrinsic coagulation pathway. FⅦa is a risk factor for pulmonary thromboembolism and may be more sensitive than FⅦc or FⅦag.