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首先描述硒化合物能降低化学致癌率的是Clayton 和Banmann(1949年)。他们在单独给予20周3’-MeDAB(3’-甲基-4-二甲基偶氮苯)的大鼠中,发现肝肿瘤的发生率为12/13,而在并用亚硒酸钠(每公斤饲料中含5 mg 亚硒酸钠)的大鼠中,肝肿瘤的发生率则为6/22。此后有关报导逐渐增多,例如Harr 等(1973年)在大鼠中观察到硒可使FAA(N-2-芴基乙酰胺)诱发肝瘤率降低,Shamberger(1970
Clayton and Banmann (1949) first described the ability of selenium compounds to reduce the rate of chemical carcinogenesis. They found that the incidence of liver tumors was 12/13 in rats given 3-MeDAB (3’-methyl-4-dimethylazobenzene) for 20 weeks alone, whereas in rats treated with sodium selenite ( In rats containing 5 mg of sodium selenite per kg of feed, the incidence of liver tumors was 6/22. Since then there has been an increasing number of reports. For example, Harr et al. (1973) observed that selenium reduced the rate of hepatic tumors induced by FAA (N-2-fluorenyl acetamide) in rats. Shamberger (1970