血管内皮生长因子-A(VEGF-A)是一种蛋白质,在血管生成和肿瘤发生中具有关键作用。人源化抗VEGF-A单克隆抗体Bevacizumab(美国Genentech公司的抗癌药,商品名Avastin)已获得美国食品和药品管理局(FDA)的批准上市用于一线药物结合化学疗法治疗转移性结直肠癌和非鳞状上皮细胞、非 Vascular endothelial growth factor-A (VEGF-A) is a protein that plays a key role in angiogenesis and oncogenesis. Humanized anti-VEGF-A monoclonal antibody Bevacizumab (Avastin, an anti-cancer drug from Genentech, USA) has been approved by the U.S. Food and Drug Administration (FDA) for first-line drug combination chemotherapy in the treatment of metastatic colorectal Cancer and non-squamous epithelial cells, non