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应用ELISA法检测了慢性乙型肝炎（CH）、慢性重症乙型肝炎（CSH）、乙型肝炎性肝硬化（HC）患者血清中TNFα、IL－1和IL－8活性。结果表明，3组病人血清中TNF－α、IL－1和Il－8活性明显高于正常对照组（P＜0．01），且CSH组血清中TNF－α、IL－1和IL－8活性明显高于CH和HC组。血清胆红素水平与TNF－α、IL－1和IL－8活性呈正相关，HBV－DNA、HBeAg阳性患者血清TNF－α、IL－1和IL－8活性明显高于阴性患者，提示TNF－α、IL－1和IL－8活性与病毒复制相关。
The serum levels of TNFα, IL-1 and IL-8 in patients with chronic hepatitis B (CH), chronic severe hepatitis (CSH) and hepatitis B cirrhosis (HC) were detected by ELISA. The results showed that the activities of TNF-α, IL-1 and IL-8 in the serum of the three groups were significantly higher than those in the normal control group (P <0.01). The levels of TNF-α, IL- Activity was significantly higher than CH and HC group. The level of serum bilirubin was positively correlated with the activity of TNF-α, IL-1 and IL-8. The activity of TNF-α, IL-1 and IL-8 in serum of HBV-DNA and HBeAg- Alpha, IL-1 and IL-8 activities are associated with viral replication.