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探讨了中药钩藤所含主要成分钩藤碱对血小板和红细胞的药理作用。浓度为0.325~1.30mmol/L时钩藤碱对ADP所致兔血小板聚集有明显促进解聚的作用,此作用较ASA略强。钩藤碱对正常血小板内cAMP浓度无明显影响,但显著抑制血小板聚集剂凝血酶及ADP所引起的血小板内cAMP浓度下降。钩藤碱具有明显改善红细胞变形能力的作用.
The pharmacological effects of rhynchophylline on the platelets and red blood cells were investigated. At a concentration of 0.325 to 1.30 mmol/L, rhynchophylline significantly promoted the disaggregation of rabbit platelet aggregation induced by ADP, which was slightly stronger than that of ASA. Rhynchophylline had no significant effect on the concentration of cAMP in normal platelets, but it significantly inhibited the decrease in platelet cAMP concentration caused by platelet aggregation agents thrombin and ADP. Rhynchophylline can significantly improve red blood cell deformability.