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目的了解健康人群对肠道病毒CoxA16与EV71型感染及免疫状况。方法用酶联免疫方法进行健康人群血清CoxA16与EV71 IgG检测。结果对10个年龄组1000例健康人群血清进行CoxA16与EV71 IgG检测,总阳性检出率为84.9%(849/1000);其中CoxA16 IgG阳性检出率为78.6%(786/1000),EV71 IgG阳性检出率为32.5%(325/1000),经统计学分析两者之间有显著性差异(χ2=430.3,P<0.05);CoxA16与EV71 IgG双阳性检出率为26.2%(262/1000),其中5岁及以下年龄组占62.6%。结论健康人群中CoxA16的感染高于EV71,人群广泛易感,无性别差异,病毒各型间无交叉免疫,防止托幼儿童的重复性感染是手足口病防控的重点。
Objective To understand the infection and immune status of enterovirus CoxA16 and EV71 in healthy population. Methods Serum CoxA16 and EV71 IgG were detected by enzyme-linked immunosorbent assay. Results The serum levels of CoxA16 and EV71 IgG in 1000 healthy people from 10 age groups were 84.9% (849/1000). The positive rate of CoxA16 IgG was 78.6% (786/1000), EV71 IgG The positive detection rate was 32.5% (325/1000). There was a significant difference between the two (χ2 = 430.3, P <0.05). The positive rate of CoxA16 and EV71 IgG was 26.2% (262 / 1000), of which age group of 5 years and below accounted for 62.6%. Conclusion The prevalence of CoxA16 in healthy population is higher than that in EV71. The population is widely susceptible and has no sex difference. There is no cross-immunity among all the virus types. Preventing repetitive infection in nursery and kindergarten children is the focus of hand-foot-mouth disease prevention and control.