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目的：探讨急性心肌梗塞后心室结构的变化及黄芪的干预治疗作用。方法：采用兔制备心肌梗塞模型，黄芪治疗组于术后第2日自腹腔注射黄芪2～3mL，每日2次．共3周；于术后第6周进行第2次手术，用精确天平及精密卡尺直接测量在室质量、全心质量及梗塞区、游离壁和空间隔厚度。结果：梗塞后全心质量及上空质量均增加，差异显著，经黄芪治疗后左室质量和全心质量均下降，其中全心质量尚未恢复至正常；室间隔及游离壁厚度增加，梗塞区室壁变薄，差异显著：经黄芪治疗后各项指标均恢复至接近正常。结论：急性心肌梗塞后梗塞区室壁变薄，非梗塞区心肌失代偿性增生肥厚，构成了心肌梗塞后左室重构，黄芪可逆转这一病理改变。
Objective: To investigate the changes of ventricular structure after acute myocardial infarction and the interventional treatment of Astragalus membranaceus. METHODS: A rabbit model of myocardial infarction was prepared. The astragalus treatment group received intraperitoneal injection of 2 to 3 mL of astragalus on the 2nd postoperative day, twice daily. A total of 3 weeks; at the sixth postoperative week, the second operation was performed, and the quality of the chamber, the mass of the entire heart, and the thickness of the infarcted area, free wall, and empty space were directly measured with a precision balance and a precision caliper. RESULTS: After infarction, the total heart mass and air mass increased, and the difference was significant. After treatment with Astragalus membranaceus, both the left ventricular mass and total heart mass decreased, and the total heart mass had not returned to normal. The interventricular septum and free wall thickness increased, and the infarct size increased. The wall became thinner and the difference was significant: After treatment with Astragalus, all indicators returned to near normal. CONCLUSIONS: The ventricular wall in the infarct region is thin after acute myocardial infarction, and decompensated hypertrophy of the non-infarcted myocardium constitutes left ventricular remodeling after myocardial infarction. Astragalus can reverse this pathological change.