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目的了解慢性阻塞性肺疾病(COPD)患者血清抵抗素水平及其影响因素。方法用酶联免疫分析法和放射免疫法检测38例老年COPD稳定期患者和26例健康对照者血清抵抗素、瘦素水平,同时测定第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1%预计值、FEV1/FVC、体质指数(BMI)、理想体重百分比(IBW%)。结果COPD组血清抵抗素〔(2.01±0.94)μg/L〕、瘦素〔(0.62±0.33)μg/L〕水平与对照组〔(3.27±1.96)μg/L和(1.01±0.69)μg/L〕比较,差异有统计学意义(均为P<0.01),且抵抗素与瘦素、FEV1、FEV1%预计值、FEV1/FVC呈显著正相关(r值分别为0.478、0.531、0.424、0.505,均为P<0.01)。多元逐步回归分析表明,影响COPD组抵抗素水平的主要因素是瘦素、FEV1和FEV1%预计值。结论老年COPD稳定期患者血清抵抗素水平下降,气流受限和瘦素分泌的减少与抵抗素水平的下降有关。
Objective To understand the serum resistin levels and its influencing factors in patients with chronic obstructive pulmonary disease (COPD). Methods Serum levels of resistin and leptin were measured in 38 stable COPD patients and 26 healthy controls by enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay. The forced expiratory volume in one second (FEV1), forced vital capacity (FVC) ), Predicted FEV 1%, FEV 1 / FVC, body mass index (BMI), and ideal body weight percentage (IBW%). Results Compared with the control group [(3.27 ± 1.96) μg / L and (1.01 ± 0.69) μg / L), the levels of serum resistin in the COPD group were significantly higher than those in the control group (2.01 ± 0.94 μg / L and 0.62 ± 0.33 μg / (P <0.01). There was a significant positive correlation between resistin and leptin, FEV1, FEV1% predicted value and FEV1 / FVC (r values were 0.478, 0.531, 0.424 and 0.505 , All P <0.01). Multivariate stepwise regression analysis showed that the main factors affecting the level of resistin in COPD were leptin, predicted FEV1 and FEV1%. Conclusions Serum resistin levels are decreased in elderly patients with stable COPD. The limitation of air flow and the decrease of leptin secretion are associated with the decline of resistin levels.