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MicroRNA(miRNA)是长度约为19~22个核苷酸的一类非编码小RNA,通过降解mRNA或阻止mRNA翻译在多种生理过程中发挥作用。炎症主要出现在拥有血管系统的活体组织中,当组织受到损伤影响时会产生抵抗反应,消除对组织产生危害的因子。然而,有些情况下,也可能会对组织自身产生损害。近年来,已有研究表明,炎性相关疾病在出现和发展的过程中与多种类型的miRNA有密切联系。miRNA通过与相应靶基因结合调节炎症相关的细胞因子,在炎性疾病的发生和发展中发挥重要的作用。所以,亟需对上述类型的miRNA展开系统研究,从而为治愈与之有联系的炎性疾病提供可靠的理论依据。
MicroRNAs (miRNAs) are a class of non-coding small RNAs, about 19 to 22 nucleotides in length, that play a role in a variety of physiological processes by degrading mRNA or preventing mRNA translation. Inflammation occurs primarily in living tissue that has a vasculature that produces a resistance response when the tissue is damaged, eliminating the risk of tissue damage. However, in some cases, it may also harm the organization itself. In recent years, studies have shown that inflammatory diseases are closely related to many types of miRNAs during their appearance and development. MiRNAs play an important role in the development and progression of inflammatory diseases through the regulation of inflammation-associated cytokines by binding to the corresponding target genes. Therefore, it is urgent to conduct systematic research on these types of miRNAs, so as to provide reliable theoretical basis for curing the associated inflammatory diseases.