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目的对85例自然流产绒毛标本染色体核型进行分析,探讨早期流产的原因。方法取流产绒毛细胞进行原位培养,G显带,染色体核型分析。培养失败标本以荧光原位杂交协助诊断。结果 85例早期流产患者绒毛标本染色体异常共28例,占32.94%,检出的染色体异常类型有:常染色体三体10例(35.71%),性染色体异常7例(25.00%),嵌合体2例(7.14%),三倍体6例(21.42%),四倍体1例(3.57%),双重三体1例(3.57%),结构异常1例(3.57%)。结论胎儿染色体异常是早期自然流产的重要原因,绒毛染色体检测为临床咨询提供重要的理论依据。
Objective To analyze the chromosomal karyotypes of 85 cases of spontaneous abortion, and to explore the causes of early abortion. Methods Abortion villus cells were cultured in situ, G banding, chromosome karyotype analysis. Failed specimens were cultured to aid in the diagnosis by fluorescence in situ hybridization. Results There were 28 cases (32.94%) of chromosomal abnormalities in 85 cases of early abortion, and the detected chromosomal abnormalities were as follows: autosomal trisomy 10 (35.71%), sex chromosome abnormalities 7 cases (25.00%), chimera 2 (7.14%), triploid in 6 cases (21.42%), tetraploid in 1 case (3.57%), double trisomy in 1 case (3.57%) and structural abnormality in 1 case (3.57%). Conclusion Fetal chromosomal abnormalities are an important cause of early spontaneous abortion. Chromosome detection of villi provides an important theoretical basis for clinical consultation.