肿瘤持续性生长和转移需要新生血管和淋巴管的形成,对于超过2mm的肿瘤来说,其生长必需依赖于血管再生。许多恶性肿瘤在确诊时已经发生了转移,而肿瘤组织丰富的新生血管淋巴管是肿瘤细胞转移的基础。在肿瘤新生淋巴管形成的影响因素中,最有效和特异的因子就是血管内皮细胞生长因 Tumor growth and metastasis requires the formation of neovascular and lymphatic vessels. For tumors over 2 mm, its growth must be dependent on angiogenesis. Many malignancies have already metastasized at the time of diagnosis, and tumor-rich neovascular lymphatic vessels are the basis of tumor cell metastasis. Among the influencing factors of lymphangiogenesis in tumor neoplasms, the most effective and specific factor is vascular endothelial growth factor