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卵泡刺激素(FSH)能刺激未成熟大鼠离体培养颗粒细胞的纤溶酶原激活物(PA)的产生,并呈剂量一依从性增加;已证实 PA 对卵巢的排卵有作用。Ny 等(1984)进一步证明,刺激颗粒细胞分泌的是组织型-纤溶酶原激活物(tpA),而不是尿激酶型-纤溶酶原激活物(uPA)。卵巢甾体激素等与 FSH 合并使用后,能提高卵巢 FSH-依从性 PA 的产生。用雌二醇(E_2)或孕酮单独处理培养中的颗粒细胞时,对 PA 的产生无明显影响。已知雌激素对卵巢细胞的成熟和发育超重要作用,其中包括:对颗粒细胞的增殖,增加 FSH 对颗粒细胞 cAMP 的形成,提高卵巢芳香化酶的活性等。活体动物经二乙基己烯雌酚预处理后,给予生理学浓度范围的 E_2,能增强 FSH所诱发的 PA 产生。E_2与 FSH 合并处理时,E_2的刺激作用有一时间的依赖性,即须经72h 的作用。给孕
Follicle stimulating hormone (FSH) can stimulate the immature rat in vitro granulosa cell plasminogen activator (PA) production, and a dose-dependent increase; PA has been confirmed on ovarian function. Ny et al. (1984) further demonstrated that the stimulation of granulosa cells is the tissue-type plasminogen activator (tpA), but not urokinase-type plasminogen activator (uPA). Ovarian steroid hormones, such as combined with FSH, can improve ovarian FSH-dependent PA production. Treatment of granulosa cells with estradiol (E2) or progesterone alone did not significantly affect PA production. Estrogen is known to play an important role in the maturation and development of ovarian cells, including the proliferation of granulosa cells, the formation of cAMP in granulosa cells by FSH, and the activity of ovary aromatase. After the animals were pretreated with diethylstilbestrol, E_2 in the physiological concentration range was given to enhance the PA production induced by FSH. E_2 and FSH combined treatment, E_2 stimulating effect of a time-dependent, that is to be the role of 72h. To pregnant