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目的 了解血浆内皮素 (ET)与肺炎的发生、发展及疾病的轻重程度之间的关系。方法 用放射免疫法检测 73例肺炎患儿ET。结果 重症肺炎组的ET为 (112 6 1± 2 6 74)ng L ,较普通肺炎组〔 (6 6 71± 2 0 86 )ng L〕明显升高 (P <0 0 1) ;危重度评分在 70～ 90分组〔 (131 18± 2 7 33)ng L〕明显高于评分大于 90分组〔(73 95± 2 4 0 5 )ng L〕 (P <0 0 0 1)。结论 ET参与重症肺炎的发生与发展 ,与疾病轻重呈相关性 ,或许能为临床诊断、治疗和判断预后提供新的途径。
Objective To understand the relationship between plasma endothelin (ET) and the occurrence and development of pneumonia and the severity of disease. Methods Radioimmunoassay was used to detect ET in 73 children with pneumonia. Results The ET in severe pneumonia group was (112 6 1 ± 2 6 74) ng L, which was significantly higher than that in common pneumonia group [(6 6 71 ± 20 86) ng L] (P 0 01) (131 18 ± 2 7 33) ng L] in the 70-90 group was significantly higher than those in the group of scores greater than 90 (73 95 ± 2 455 ng L) (P 0 01). Conclusions The involvement of ET in the occurrence and development of severe pneumonia is related to the severity of the disease, which may provide a new approach for clinical diagnosis, treatment and prognosis.