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中医药具有多组分、多途径、多层次和多靶点的作用特点,在防治颈动脉粥样硬化的发生和发展中的作用机制主要涉及到抑制炎性反应,稳定易损斑块;降低氧化应激反应,保护血管内皮功能,抑制血管平滑肌细胞增殖;抑制血管壁的微血管新生,增加斑块稳定性;上调VEGF的表达,促进血管内皮细胞修复与新生;减少基质金属蛋白酶表达,抑制斑块增殖和破溃等,延缓动脉粥样硬化病变的发展,抑制斑块内出血、溃疡及斑块脱落,减少心脑血管病事件的发生。
Traditional Chinese medicine has multi-component, multi-path, multi-level and multi-target role in the prevention and treatment of carotid atherosclerosis in the pathogenesis and development of the mechanism mainly involves the inhibition of inflammatory response, stable and vulnerable plaque; reduce Oxidative stress response, protect vascular endothelial function, inhibit the proliferation of vascular smooth muscle cells; inhibit angiogenesis, increase plaque stability; upregulate the expression of VEGF, promote endothelial cell repair and newborn; reduce the expression of matrix metalloproteinase, Block proliferation and ulceration, etc., to delay the development of atherosclerotic lesions, inhibit plaque hemorrhage, ulcers and plaque loss, reduce the occurrence of cardiovascular and cerebrovascular events.