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目的 查明全民食盐加碘后贵州省儿童甲状腺肿大 (甲肿 )率消长反常现象的原因。方法 采用点面结合的“典型调查”方法 ,即先用触诊法初筛贵州省 19所小学校的适龄儿童 ,然后从中遴选出 度甲肿率较高的并有层次代表性的 3所学校纳入全面调研的视野。结果 儿童甲肿率消长反常现象在贵州省较为普遍 ,甲肿病情严重程度的排序是村屯级 >乡镇级 >县城级 >省城级。结论 高甲肿率与当地多种因素密切相关 ,水硬度大、辣椒氟严重超标以及贫困等因素在致病过程中发挥着修饰性放大作用。这一结论有待进一步通过病例对照研究和前瞻性队列研究证实。
Objective To find out the causes of the abnormal growth of goiter (goiter) rate in children in Guizhou Province after the salt is iodized by the whole people. Methods The “typical survey” method using point-to-area combination was adopted, that is, first to screen the school-age children in 19 primary schools in Guizhou Province by palpation method, and then select the three schools with higher degree of tumor deformity and level representation Comprehensive research vision. Results The abnormal rate of children with hypothyroidism was more common in Guizhou Province. The order of the severity of the disease was village level> township level> county level> provincial level. Conclusions The rate of severe hypothyroidism is closely related to many local factors. The factors such as high water hardness, serious excessive fluoride in peppers, and poor factors play a role of modification and amplification in pathogenesis. This conclusion needs to be further confirmed by case-control studies and prospective cohort studies.