冷冻疗法是1998年美国FDA、1999年中国SDA批准的新疗法。其基本原理是:将癌组织快速冷至-160℃以下,再复温,可直接引起癌细胞脱水和破裂,或破坏肿瘤小血管而致缺氧,导致瘤细胞死亡。冷消融后留在原位的死亡肿瘤组织,可作为抗原,促进机体发生抗肿瘤免疫反应。冷冻后的癌细胞对化疗或放疗更敏感,即可增强化疗或放疗的作用。1治疗过程冷冻可在手术中、内镜下或经皮穿刺进行。经皮冷冻最常用,系应用超声或CT引导下,将冷冻探针插入肿瘤内, Cryotherapy is a new treatment approved by the U.S. FDA in 1998 and China SDA in 1999. The basic principle is: the cancer tissue quickly cooled to -160 ℃ below, and then re-temperature, can directly cause cancer cells dehydration and rupture, or destroy the small blood vessels caused by hypoxia, leading to tumor cell death. After death, the tumor remains in situ after cold ablation and can be used as an antigen to promote the body’s anti-tumor immune response. Frozen cancer cells are more sensitive to chemotherapy or radiotherapy, which can enhance the role of chemotherapy or radiotherapy. 1 treatment can be frozen during surgery, endoscopic or percutaneous puncture. Percutaneous freezing most commonly used, Department of ultrasound or CT guidance, the frozen probe into the tumor,