粒-巨噬细胞集落刺激因子(GM-CSF)有刺激前期中性粒细胞生长和激活已产生的中性粒细胞的潜能。本文报告2例急性淋巴细胞白血病(ALL)化疗后引起中性粒细胞极度减少且并发感染。用 GM-CSF治疗获得成功。并证明使用 GM-CSF 不会刺激白血病细胞的生长。病例报告例1:男,23岁,因发热、淋巴结增大、脾大、白细胞150 000/mm~3、骨髓活检及涂片检查诊断 ALL。免疫分型属前 B 细胞。化疗后骨髓增生极度低下,出现软颚糜烂,活检证实为念珠菌感染。用两性霉素0.6mg/kg/d,,持 Granulocyte-macrophage colony-stimulating factor (GM-CSF) has the potential to stimulate neutrophil growth and to activate neutrophils that have been produced. This article reports 2 cases of acute lymphoblastic leukemia (ALL) chemotherapy caused by extremely reduced neutrophils and concurrent infections. Success with GM-CSF treatment. And demonstrated that the use of GM-CSF does not stimulate the growth of leukemia cells. Case report: Male, 23 years old, due to fever, increased lymph nodes, splenomegaly, white blood cells 150 000 / mm ~ 3, bone marrow biopsy and smear diagnosis of ALL. Immunophenotyping is pre-B cells. Bone marrow hyperplasia after chemotherapy is extremely low, there is soft jaw erosion, biopsy confirmed as Candida infection. With amphotericin 0.6mg / kg / d ,, holding