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目的了解阿尔茨海默病患者的医院感染状况及影响因素,为制定控制措施提供指导。方法对医院2012年1月-2014年4月收治的80例阿尔茨海默病患者进行前瞻性调查,并对医院感染的相关影响因素进行logistic回归分析,研究数据采用SPSS17.0软件进行统计分析。结果 80例阿尔茨海默病患者发生医院感染24例,感染率为30.00%;主要感染部位为呼吸道,占16.25%;检出主要病原菌为铜绿假单胞菌、表皮葡萄球菌、大肠埃希菌,分别占30.00%、25.00%、15.00%;多元回归分析结果显示,住院时间、侵入性操作、阿尔茨海默病病程以及抗菌药物使用时间等是医院感染发生的独立危险因素(P<0.05)。结论阿尔茨海默病患者的医院感染率较高,与多种因素有关,主要感染部位为呼吸道,应加强医院感染控制。
Objective To understand the status and influencing factors of nosocomial infections in patients with Alzheimer’s disease and to provide guidance for the development of control measures. Methods 80 patients with Alzheimer’s disease who were hospitalized from January 2012 to April 2014 in our hospital were prospectively investigated. Logistic regression analysis was conducted on the factors influencing nosocomial infection. The data were analyzed by SPSS17.0 software . Results Twenty-four cases of nosocomial infections were found in 80 Alzheimer’s patients, the infection rate was 30.00%. The main infection sites were respiratory tract, accounting for 16.25%. The main pathogenic bacteria were Pseudomonas aeruginosa, Staphylococcus epidermidis, Escherichia coli , Respectively, accounting for 30.00%, 25.00% and 15.00%, respectively. Multivariate regression analysis showed that hospitalization time, invasive procedures, Alzheimer’s disease duration and duration of antimicrobial agents were independent risk factors for nosocomial infections (P <0.05) . Conclusion The prevalence of nosocomial infections in patients with Alzheimer’s disease is high, which is related to many factors. The main infection sites are respiratory tract, and nosocomial infection control should be strengthened.