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采用高铁血红蛋白还原定性法,再用NBT定量法对湛江地区围产期夫妇3766人做了G6PD缺乏症基因频率的调查,对地中海贫血性状(杂合体)进行了筛查。结果示:该群体G6PD缺乏症基因频率为0.0508,介于广西钦州(0.0402)和海南白沙汉族(0.0638)之间。地中海贫血性状发生率为5.74％,其中α地贫约两倍于β地贫,而β地贫以HbA_2增高型多见。以该调查资料估算,湛江群体Bart’s水肿胎发生率为0.036％,重型β地贫为0.01％。
Using qualitative methemoglobin reduction method, NBT quantitative method was used to investigate the frequency of G6PD deficiency gene in 3766 perinatal couples in Zhanjiang. The thalassemia trait (hybrid) was screened. The results showed that the frequency of G6PD deficiency gene in this population was 0.0508, which was between Qinzhou (0.0402) in Guangxi and that in Hainan (0.0638). The incidence of thalassemia trait was 5.74%, of which, thalassemia was about twice as high as thalassemia, and thalassemia was more common in HbA 2 -related cases. According to the survey data, the incidence of Bart’s edema was 0.036% in Zhanjiang and 0.01% in severe β-thalassemia.