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目的探讨甲钴胺联合高压氧治疗对糖尿病足患者肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)及白细胞介素-6(IL-6)水平的影响。方法选取2013年3月至2015年1月吉林省人民医院收治的90例糖尿病足患者作为研究对象,按随机数字表法将其分为观察组和对照组,各45例。两组患者均给予常规治疗,在此基础上对照组患者肌内注射甲钴胺注射液,观察组患者在对照组基础上采用高压氧进行治疗,比较两组患者的治疗效果及治疗前后TNF-α、CRP及IL-6水平。结果观察组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的TNF-α、CRP及IL-6水平均明显低于对照组,差异均有统计学意义(均P<0.05)。结论甲钴胺联合高压氧治疗糖尿病足患者的效果明显优于单独应用甲钴胺,可以有效改善机体炎性反应。
Objective To investigate the effects of mecobalamin combined with hyperbaric oxygen on the levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP) and interleukin-6 (IL-6) in diabetic foot patients. Methods Ninety patients with diabetic foot admitted to Jilin Provincial People’s Hospital from March 2013 to January 2015 were selected as study subjects, and randomly divided into observation group and control group according to random number table method, with 45 cases in each group. Both groups were given conventional treatment, on the basis of intramuscular injection of mecobalamin in the control group, the observation group were treated with hyperbaric oxygen on the basis of the control group, the treatment effect of the two groups were compared and the levels of TNF- α, CRP and IL-6 levels. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). After treatment, the levels of TNF-α, CRP and IL-6 in observation group were significantly lower than those in control group The differences were statistically significant (all P <0.05). Conclusion Mecobalamin combined with hyperbaric oxygen treatment of diabetic foot patients was significantly better than mecobalamin alone, can effectively improve the body’s inflammatory response.