应用降眼压药物是青光眼治疗的主要方式,但临床中可观察到患者对降眼压药物反应性存在差异.不同人种对前列腺素类药物滴眼液的反应性不同;同一患者对同属前列腺素类不同降眼压药物的反应性也不同;随着用药时间的延长,部分患者对降眼压药物由不反应的状态转变为有反应的状态.产生药物治疗个体反应差异的原因比较复杂,目前认为药物靶点和药物代谢相关基因的多态性是引起药物反应个体差异的主要原因.通过研究降眼压药物作用相关基因的差异与临床反应的关系,能够使青光眼的个性化治疗成为可能.本文对降眼压药物反应性及相关影响因素进行总结与讨论,希望对临床个体化用药、精准治疗和相关研究提供帮助.“,”The application of antiglaucoma drugs is the main treatment for glaucoma,but there are differences in the response of patients to antiglaucoma drugs.Different races have different reactivities to prostaglandins;the same patient may has different reactivity to different prostaglandins;with the prolonged use of prostaglandins,the status of some patients have changed from being unresponsive to being reactive.The reasons for individual difference of drug response are complex.Drug receptor and metabolism gene polymorphisms are deemed as the cause of individual difference.Studying the relationship between drug responses and gene differences can realize individual therapy.This review summarized the response to antiglaucoma drugs and influence factors leading to individual difference of drug response,which may provide help for clinical individualized and precise treatment.