五十年代以来,随着糖皮质激素在临床上的广泛应用,人们注意到,长期大量地应用糠皮质激素容易诱发胃溃疡。目前认为,糖皮质激素诱发溃疡的原因之一是影响胃酸分泌,因此探讨糖皮质激素影响胃酸分泌的机制,有一定的理论和实际意义。 已有的研究资料表明,糖皮质激素对组胺,氨甲酰胆素和五肽胃泌素的促泌酸作用起 Since the 1950s, as glucocorticoid has been widely used clinically, it has been noticed that the long-term use of pullulan in large quantities easily causes gastric ulcer. It is currently believed that one of the causes of glucocorticoid-induced ulcer is the impact of gastric acid secretion, so to explore the mechanism of glucocorticoid affect gastric acid secretion, have some theoretical and practical significance. Existing research data show that glucocorticoid on histamine, carbamyl and pentagastrin secretion of acid-stimulating effect