论文部分内容阅读
用光镜体视学方法，结合电镜观察，探讨发生侧支出芽和重建突触的背根节神经元，其胞体是否也呈现相应的形态变化，以及吗啡对这些变化的影响。吗啡备用根组和备用根对照组的大鼠术侧背根节体积与非术侧比较，均没有明显的统计学差异；其亮神经元胞体、胞核和核仁的体积也没有显著性差异。对照组非术侧亮神经元胞体的尼氏体呈颗粒状，多聚核糖体聚集成小簇，分散在胞质中。术侧尼氏体则呈小块状，多聚核糖体簇较大，较为密集。吗啡组术侧亮神经元胞体的尼氏体也在胞核周围聚集成小块状，有些还呈斑块样。此时可见多聚核糖体呈团簇状，其分布更为密集。这种变化可能与发出有髓传入纤维的亮神经元在脊髓内侧支出芽及重建突触有关。对照组术侧暗神经元胞体、胞核和核仁的体积，比非术侧显著增大。吗啡组术侧暗神经元胞体、胞核和核仁的体积又比对照组术侧的大，而且胞质的多聚核糖体和粗面内质网明显增多，表明与无髓传入纤维在脊髓侧支出芽及重建突触有关的暗神经元胞体也发生了相应的形态变化，吗啡对这些变化有明显的促进作用。
Using light microscopy and electron microscopy to explore the occurrence of dorsal budding and reconstruction of synaptic dorsal root ganglion neurons, the cell body also showed the corresponding morphological changes, and morphine on these changes. There was no significant difference in the volume of dorsal root ganglion between the morphine standby root group and the backup root control group at the time of operation, and there was no significant difference in the volume of bright cell neurons, nucleus and nucleolus . In the control group, the Nissl bodies of the non-operative bright neurons were granular, and the polyribosomes clustered into small clusters and dispersed in the cytoplasm. Artery nodules were small lumps, polyribosomes larger, more dense. Morphine group surgery side of bright neuronal somatic Nissan body also gathered around the nucleus into small pieces, some were also plaque-like. Polyribosomes were clustered at this time and their distribution was more intensive. This change may be associated with the release of neurons from the medullary afferent fibers in the medullary sprouting and reconstruction synapses. The volume of dark cells, nuclei and nucleolus in the control group were significantly increased than those in the non-operation side. Morphine group darker neurons on the operation side of the volume of the cell body, nucleus and nucleolus larger than the control group, and the cytoplasm of the polyribosomal and rough endoplasmic reticulum was significantly increased, indicating no afferent fibers in the pulp Spinal cord branches budding and reconstruction of synaptic dark cell bodies also occurred the corresponding morphological changes, morphine significantly promote these changes.