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分离了广州本地蚯蚓的体腔液,制成冻干粗粉。以纤维蛋白平板法检查了冻干粗粉的溶纤维蛋白活性。结果,5μg冻干粗粉与1 Iu尿激酶活性相当。冻干粗粉还能使经85℃,30分钟加热平板的纤维蛋白溶解,但作用较弱。按Umetsu等的方法,观察了蚯蚓体腔液冻干粗粉(30mg/kg体重,经腹部切口注入十二指肠,30分钟后作血管插管),对纤维蛋白生成的抑制率为59.01±25.89%;尿激酶(1500 Iu/kg体重,插管后立即静注)对纤维蛋白生成的抑制率为62.43±15.26％。两者无差别(P>0.50)。
Isolated Guangzhou local earthworm body fluid, made of lyophilized meal. The fibrin plate assay was used to examine the fibrinolytic activity of lyophilized meal. As a result, 5 μg of lyophilized meal is comparable in activity to 1 u of urokinase. The lyophilized meal also solubilized the fibrin plate heated at 85 ° C for 30 minutes, but the effect was weaker. According to the method of Umetsu et al., The freeze-dried meal of the earthworm body cavity (30 mg / kg body weight, injected into the duodenum through the abdominal incision and blood vessel intubation after 30 minutes) was observed. The inhibition rate on fibrin production was 59.01 ± 25.89 %; Inhibition of fibrin production by urokinase (1500 Iu / kg body weight, intubation immediately after intubation) was 62.43 ± 15.26%. There was no difference between the two (P> 0.50).