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目的探讨糖皮质激素的抗痫效应。方法应用脑电图仪和免疫细胞化学方法，分别研究地塞米松对马桑内酯或戊四氮致痫大鼠的脑电图（ＥＥＧ）和代谢型谷氨酸受体１α（ｍＧｌｕＲ１α）免疫反应性的影响，并观察大鼠行为的改变。结果大鼠注射马桑内酯或戊四氮前３０ｍｉｎ经静脉注入地塞米松，能防止严重的癫痫发作症状和脑电图中高电位的痫波发放，并能减少ｍＧｌｕＲ１α在海马区的表达。结论地塞米松具有抑制马桑内酯或戊四氮诱发癫痫的作用，海马内的ｍＧｌｕＲ１α可能在癫痫活动中起一定作用，地塞米松的抗痫效应可能与降低ｍＧｌｕＲ１α的表达有关。
Objective To investigate the anti-epileptic effects of glucocorticoids. Methods EEG and immunocytochemistry were used to study the effects of dexamethasone on the electroencephalogram (EEG) and metabotropic glutamate receptor 1α (mGluR1α) Reactivity, and observe the changes in behavior of rats. Results Intravenous injection of dexamethasone 30 min before injection of either macassolactone or pentylenetetrazole prevented severe seizures and release of epileptic waves with high potential in EEG and decreased the expression of mGluR1α in hippocampus. Conclusion Dexamethasone inhibits the effects of either ornithine or pentylenetetrazol on epilepsy. The mGluR1α in hippocampus may play a role in the activity of epilepsy. The anti-epileptic effect of dexamethasone may be related to the decrease of mGluR1α expression.