论文部分内容阅读
目的:探讨人类胚胎脑动脉分叉部弹力纤维和中层平滑肌细胞(Smoothmusclecell,SMC)的构筑发育过程及特点,以助对脑动脉瘤病因假说的理解和验证。方法:收集胎龄12～28周人类胚胎共17例,每1个周龄取1例,男女不限。对胎脑Willis环周围的动脉分叉部行不同方向组织切片,观察弹力纤维和中层SMC的构筑发育过程。结果:胎脑Willis环周各动脉弹力纤维在1.5～12.6层之间,弹力纤维在同一切片有紊乱和逐渐减少现象,内弹力层第19周发育完整;中层SMC在1.1～9.0层之间,70.6%的胎脑动脉个别分叉部发现中层SMC缺陷,所取标本的30.3%发现中层SMC缺陷。结论:胎脑动脉内弹力纤维和中层SMC随胎龄增长而增多,内弹力层于第13～19周出现并发育成熟,脑动脉分叉部存在先天性SMC缺陷、弹力纤维紊乱和逐渐减少现象,有助于对脑动脉瘤病因假说的理解和验证。
OBJECTIVE: To investigate the development and characteristics of the elastic fibers and smooth muscle cells (SMCs) at the bifurcation of human embryos in order to help understand and validate the causal hypothesis of cerebral aneurysms. Methods: A total of 17 human embryos of 12-28 gestational weeks were collected, one for every 1 week of age. Fetal Willis ring around the bifurcation of the arteries around the line of different directions of the organization to observe the elastic fibers and the middle of SMC construction and development process. Results: Willis around the arterial elastic fibers in the 1.5 to 12.6 between the layers of elastic fibers in the same section of a disorder and a gradual decrease in the development of the inner elastic layer at 19 weeks complete; SMC in the middle of 1.1 to 9.0 between the layers, The middle SMC defect was found in 70.6% of the individual bifurcation of the fetal brain artery, and 30.3% of the specimens were taken to find the middle SMC defect. Conclusions: The intramyocardial elastic fibers and middle SMC increased with the increase of gestational age. The inner elastic layer appeared and developed from the 13th to the 19th week. The cerebral arterial bifurcation had congenital defects of SMC, disorganized elastic fibers and gradual decrease , Helps to understand and verify the etiology of cerebral aneurysm.