Background Transcatheter aortic valve implantation (TAVI) is a rapidly evolving strategy for therapy of aortic stenosis.We presented the procedural results and analyzed the death causes of 30-day mortality and clinical events in patients who underwent TAVI with Edwards prosthetic valves in University Hospital of Caen,France.Methods The patients with severe aortic stenosis but at high surgical risk or inoperable were considered as candidates for TAVI.Forty-eight patients undergoing TAVI from July 2010 to September 2011 were enrolled in this registry.The Edwards prosthetic valves were solely used in this clinical trial.Results Overall 48 patients underwent TAVI,28 of which accepted TAVI by trans-femoral (TF) approaches,20 by trans-apical approaches (TA).The aortic valve area (AVA) was (0.70±0.23) cm2,left ventricular ejection fraction (LVEF)was (57.4±17.6)％,Log EuroSCORE was (19.2±15.8)％,mean gradient was (47.0±16.6) mmHg.There were no significant differences between TF and TA groups in all these baseline parameters.Device success rate was 95.8％,and procedural success rate was 93.7％ in total.Procedural mortality was 6.7％ (3/48):two deaths in TA group (10％),and one death in TF group (3.6％).Forty-six Edwards valves were implanted:10 Edwards Sapien and 36 Edwards XT.Procedure-related complications included cardiac tamponade in 2 cases (4.2％),acute myocardial infarction (AMI) in 1 case (2.1％),permanent pacemaker implantation in 1 case (2.1％),life-threatening and major bleeding in 3 cases; access site related major complication in 1 case,AKI stage 3 in 3 cases (6.3％),minor stroke in 1 case (2.1％).Thirty-day survival rate was 89.6％.There were 5 deaths in total (10.4％):4 in TA group (20％) and 1 in TF group (3.6％).Conclusion The procedural success rate and 30-day mortality were acceptable in these high risk patients with Edwards prosthetic valves in the first 48 TAVI.