非心源性胸痛与食管压力不正常疾病有联系,其中以表现为高幅蠕动性收缩的胡桃夹食管(nutcrack-er esophagus)最常见。本文对照研究作用较长的钙通道阻断剂硫氮(艹卓)酮对改善此类患者症状和降低食管压力的作用。 22例非心源性胸痛及/或吞咽困难而有高幅收缩的患者接受为期16周的双盲交叉研究。用药前,远段食管〔下食管括约肌(LES)上3或8cm〕之平均蠕动压≥125mmHg者称胡桃夹食管。22例患者中之14例(女8例,女6例,平均年龄50岁)完成本研究(研究组),平均最大食管蠕动压为191±51mmHg,而40名平均年龄为32岁的健康志愿者则为81±15mmHg。研究组中有12例胸痛反复发生至少6个月,其中10例至少有一个其他食管症状,男2例无胸痛者有食管 Non-cardiogenic chest pain is associated with an esophageal pressure disorder, with nutcrack-es esophagus exhibiting a high rate of peristaltic contractions. In this paper, we investigated the role of long-acting calcium channel blocker, azithromycin, in improving symptoms and reducing esophageal pressure in these patients. Twenty-two patients with non-cardiac chest pain and / or high-grade contractions with dysphagia underwent a 16-week double-blind crossover study. Before treatment, distal esophageal [lower esophageal sphincter (LES) 3 or 8cm] average creep pressure ≥ 125mmHg said nutcracker esophagus. Fourteen patients (8 males and 6 females, mean age 50 years) of 22 patients completed the study (study group) with an average maximal motility of 191 ± 51 mmHg and 40 healthy volunteers, mean age 32 years Then 81 ± 15mmHg. In the study group, 12 cases of recurrent chest pain for at least 6 months, of which 10 had at least one other esophageal symptoms, 2 men without chest pain were esophageal