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目的探讨C-反应蛋白(CRP)对早期识别重症手足口病的临床意义。方法收集我院2010年4月～10月收治的190例手足口病住院患儿,其中普通病例110例,重症病例80例,测定入院时和治疗5d后CRP。结果 CRP>10mg/L阳性,入院时普通病例组C-反应蛋白升高病例数占总病例数的7.27%,重症病例组C-反应蛋白升高病例数占总病例数的88.75%,重症病例CRP阳性率明显高于普通型病例,两者差异有显著性(P<0.01),治疗5天后普通病例组C-反应蛋白均降至正常,重症病例组C-反应蛋白升高病例数占总病例数的6.25%,与治疗前相比阳性率明显降低(P<0.01)。结论 CRP对判断手足口病病情严重程度、早期识别重症病例有一定价值。
Objective To investigate the clinical significance of C-reactive protein (CRP) in the early identification of severe hand-foot-mouth disease. Methods Totally 190 children with hand-foot-mouth disease were collected from April 2010 to October 2010 in our hospital. Among them, 110 were common and 80 were severe. CRP was measured at admission and 5 days after treatment. Results CRP> 10mg / L was positive. The incidences of elevated C-reactive protein were 7.27% in the common cases, 88.75% in the severe cases, and 88.75% in the severe cases CRP positive rate was significantly higher than the common type of cases, the difference was significant (P <0.01), 5 days after treatment, normal cases of C-reactive protein were normal, severe cases of C-reactive protein increased the total number of patients The number of cases was 6.25%, which was significantly lower than that before treatment (P <0.01). Conclusion CRP is of certain value in judging the severity of hand-foot-mouth disease and identifying severe cases in early stage.