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铝是一种常见的金属元素,其神经毒性可能是影响学习记忆机制的因素之一。突触传递长时程增强(LTP)是研究学习记忆的一个可用电生理模型,cAMP蛋白激酶A(PKA)途径是神经元重要的信号传导通路,在学习记忆形成过程中起重要的作用。铝可以影响学习记忆机制中某些环节(如神经递质、钙离子浓度、蛋白激酶等),导致智力及认知能力的下降。该文根据近年来国内外在该领域的研究进展,从电生理学、生物化学等方面阐述了铝对学习记忆机制的影响及与cAMP/PKA途径的关系。
Aluminum is a common metal element, and its neurotoxicity may be one of the factors that affect the learning and memory mechanism. Synaptic transmission Long-term potentiation (LTP) is an available electrophysiological model for studying learning and memory. The cAMP protein kinase A (PKA) pathway is an important signal transduction pathway in neurons and plays an important role in learning and memory formation. Aluminum can affect some aspects of learning and memory mechanisms (such as neurotransmitter, calcium ion concentration, protein kinase, etc.), resulting in decreased intelligence and cognitive ability. According to the research progress in this area at home and abroad in recent years, the paper expounds the influence of aluminum on learning and memory mechanism and its relationship with cAMP / PKA pathway from the aspects of electrophysiology and biochemistry.