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尿酸是人机体嘌呤代谢后的终末产物,主要经肾脏随尿液排泄.机体嘌呤的合成,吸收和分解代谢紊乱或尿酸排泄障碍常可致高尿酸血症.近年深入研究发现血清尿酸水平与糖尿病、代谢综合征、心脑血管疾病,高血压等密切相关.血清尿酸水平持续升高所致的高尿酸血症,也可能是一组多基因遗传性疾病,“与亚甲基四氢叶酸还原酶(Methylenetetrahydrofolate reductase,MTHFR)基因突变密切相关”.肾性低尿酸血症亦具有重要的临床意义.综述了高尿酸血症实验室检测及其临床意义.“,”uric acid purine metabolism in the human body after the end products,mainly with the urine excreted by the kidneys.Body purine synthesis,absorption and excretion of uric acid catabolism disorders or disorder often can cause hyperuricemia.In recent years,in-depth study found that serum uric acid levels and diabetes,metabolic syndrome,cardiovascular disease,high blood pressure are closely related.Serum uric acid(SUA) levels continue to rise due to hyperuricemia(HUM),it may be a polygenic disease,“and the methylenetetrahydrofolate reductase(Methylenetetrahydrofolate reductase,MTHFR) gene mutation closely related to.”Low serum uric acid kidney also has important clinical significance.Overview of hyperuricemia and its clinical significance of laboratory tests.