氨甲喋呤(Methotrexate,MTX)用于抗风湿治疗已逾40年,具见效快、疗效好、经济、简便等优点,被誉为“和激素一样不需统计学证明的有效抗炎药”,其对类风湿关节炎(RA)的疗效相当或优于硫唑嘌呤,D-青霉胺,抗疟药和金制剂等慢作用抗风湿药,在其它风湿性疾病中的应用也日渐广泛,现将近年来MTX在抗风湿治疗中的应用进展综述如下。 Methotrexate (MTX) has been used for anti-rheumatic therapy for more than 40 years. It has the advantages of quick effect, good curative effect, economy and simplicity. It is praised as “effective anti-inflammatory drug that does not need statistical evidence as hormone” Rheumatoid arthritis (RA) is equivalent to or superior to azathioprine, D-penicillamine, anti-malarial drugs and gold preparations and other slow-acting anti-rheumatic drugs in other rheumatic diseases is also increasingly widespread application, MTX anti-rheumatic therapy in the application of progress in the past are summarized below.