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观察了低氧条件下冻伤大鼠骨骼肌水肿程度的改变。体重２００±２０ｇ雄性Ｗｉｓｔａｒ大鼠随机分为三组：平原冻伤组（ＦＮ）；急性低氧冻伤组（ＦＡＨ，模拟海拔６０００ｍ缺氧４ｈ后冻伤）和低氧习服冻伤组（ＦＨＡＣ，模拟海拔６０００ｍ每日缺氧４ｈ，连续４周后冻伤）。大鼠的右后肢冻伤后不同时间，用称量法测定冻伤肌肉中的含水量，计算其水肿程度。结果表明，各冻伤组冻后肌肉水肿程度均明显增加，其中以ＦＮ组较为严重，ＦＡＨ组肌肉水肿程度与ＦＮ组无差别，而ＦＨＡＣ组冻伤肌肉水肿程度较轻且消退较快，组织干性坏死出现较早。结果提示单纯急性低氧未加重冻伤损伤程度，而低氧习服则可加重冻伤损伤程度。
The changes of skeletal muscle edema in rats with hypoxia were observed. The weight of 200 ± 20g male Wistar rats were randomly divided into three groups: plain frostbite group (FN); acute hypoxic frostbite group (FAH, simulating hypoxia 4h after altitude frostbite) 6000m daily hypoxia 4h, 4 consecutive weeks after frostbite). At different times after the right hindlimb frostbite in rats, the water content of the frostbite muscle was measured by weighing method, and the degree of edema was calculated. The results showed that the degree of muscle edema increased significantly in each frostbite group, especially in FN group, the degree of muscle edema in FAH group was not different from that in FN group, while the degree of muscle edema in FHAC group was lighter and faded rapidly, Necrosis appeared earlier. The results suggest that acute hypoxia alone does not increase the degree of injury to the degree of frostbite, and hypoxia can increase the degree of frostbite injury.