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Excess accumulation of white adipose tissue(WAT)causes obesity which is an imbalance between energy intake and energy expenditure.Obesity is a serious concern because it has been the leading causes of death worldwide,including diabetes,stroke,heart disease and cancer.Therefore,uncovering the mechanism of obesity and discovering anti-obesity drugs are crucial to prevent obesity and its complications.Browning,inducing white adipose tissue to brown or beige(brite)fat which is brown-like fat emerging in WAT,becomes an appealing therapeutic strategy for obesity and metabolic disorders.Due to lack of efficacy or intolerable side-ef-fects,the clinical trials that promote brown adipose tissue(BAT)thermogenesis and browning of WAT have not been successful in hu-mans.Obviously,more specific means still need to be developed to activate browning of white adipose tissue.In this review,we sum-marized seven kinds of natural products(alkaloids,flavonoids,terpenoids,long chain fatty acids,phenolic acids,else and extract)pro-moting white adipose tissue browning which can ameliorate the metabolic disorders,including obesity,dislipidemia,insulin resistance and diabetes.Since natural products are important drug sources and the browning property plays a significant role in not only obesity treatment but also in type 2 diabetes(T2DM)improvement,natural products of inducing browning may be an irreplaceable drug dis-covery orientation for obesity,diabetes and even other metabolic disorders.