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目的:探讨益气活血化痰通络汤联合高压氧治疗对急性脑梗死患者血流动力学的影响及疗效。方法:选取2016年1月至2019年1月温岭市中医院神经内科收治的80例急性脑梗死患者，随机分为对照组和研究组，每组40例；对照组应用高压氧治疗，研究组在高压氧治疗基础上增加益气活血化痰通络汤治疗。2组均采用美国国立卫生研究院卒中量表(NIHSS)评价治疗效果；应用酶联免疫吸附法(ELISA)检测炎性因子；应用ELISA试剂盒检测神经功能；抽取患者治疗前后空腹静脉血，检测氧化应激反应；应用颅多普勒超声检测血流动力学指标。结果:研究组疗效优于对照组，总体有效率分别为97.2%和82.5%，组间比较差异有统计学意义(n P<0.05)；治疗后，研究组C反应蛋白(CRP)、白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)等炎性因子水平均低于对照组，差异均有统计学意义(n P<0.05)；研究组心脏型脂肪酸结合蛋白(H-FABP)、神经元特异性烯醇化酶(NSE)、胶质纤维酸性蛋白(GFAP)、脑特异性蛋白(S100B)、髓鞘碱蛋白(MBP)等神经功能指标均低于对照组，差异均有统计学意义(n P<0.05)；研究组超氧化物歧化酶(SOD)水平高于对照组，丙二醛(MDA)、活性氧(ROS)水平低于对照组，差异均有统计学意义(n P<0.05)；研究组大脑中动脉(MCA)、椎动脉(VA)收缩期峰值流速(Vs)、舒张期末流速(Vd)、平均血流速度(Vm)均高于对照组，搏动指数(PI)、阻力指数(RI)均低于对照组，差异均有统计学意义(n P<0.05)。n 结论:对急性脑梗死患者采用中药联合高压氧治疗，临床效果理想，可降低炎性因子水平，改善患者应激反应、神经功能及血流动力学指标，对日常生活能力恢复具有较高的临床价值。“,”Objective:To explore the effect of Yiqi Huoxue Huatan Tongluo Decoction (a formula of traditional Chinese medicine for invigorating qi, activating blood circulation, resolving phlegm, and dredging collaterals) combined with hyperbaric oxygen on hemodynamics of patients with acute cerebral infarction and its efficacy.Methods:A total of 80 patients with acute cerebral infarction, admitted to Wenling Hospital of Traditional Chinese Medicine from January 2016 to January 2019, were randomly divided into the control group and the study group with 40 cases in each group. The control group was treated with hyperbaric oxygen therapy, while the study group was treated with Yiqi Huoxue Huatan Tongluo Decoction on the basis of the treatment of the control group. The curative effects were evaluated by the National Institutes of Health Stroke Scale (NIHSS). The inflammatory factors were detected by enzyme-linked immunosorbent assay(ELISA). The nerve function was detected by the ELISA kit. Fasting venous blood was collected from patients before and after treatment to detect oxidative stress response. The hemodynamic indexes were detected by transcranial Doppler ultrasound.Results:The curative effect of the study group (97.2%) was better than that of the control group (82.5%), the difference was statistically different (n P<0.05); after treatment, the levels of inflammatory factors such as CRP, IL-1, TNF-α, and IL-6 in the study group were lower than those of the control group (n P<0.05); the nerve function indexes of H-FABP, NSE, GFAP, S100B, and MBP in the study group were lower than those in the control group (n P<0.05); the level of SOD in the study group was higher than that of the control group, and the MDA and ROS levels were lower than those of the control group (n P<0.05); in MCA and VA, the indexes of Vs, Vd, Vm in the study group were higher than those of the control group; in MCA and VA, the PI and RI of the study group were lower than those of the control group (n P<0.05).n Conclusion:Yiqi Huoxue Huatan Tongluo Decoction combined with hyperbaric oxygen therapy can achieve a satisfactory curative effect on patients with acute cerebral infarction, through reducing the levels of inflammatory factors, improving the stress response, neurological function and hemodynamic indexes of patients, which has a high clinical value for the recovery of patients′ activity of daily life.