制霉菌素(下简称NM)已制成几种剂型,如内服片剂和丸剂以及外用栓剂和阴道片剂等。前曾指出,NM受光线,特别是紫外线和储存温度所影响,在温度5°以下避免储存时干粉的效价每月下降1～2%。也有指出,NM粉末在冷冻条件下稳定,但温度升高则分解;在100°时其抗菌活力在三小时内可损失75%;湿度和PH也影响其稳定性。作者发现,NM制剂的稳定性与其粉末者不同,其片剂有某些保护作用;加四环素能改善其抗菌稳定性。本文研究了单独NM及其在五种不同栓剂基质中在不同温度下的稳定性。实验:制霉菌素(美国药典规格);细菌 Nystatin (hereinafter referred to as NM) has been made into several formulations, such as oral tablets and pills and topical suppositories and vaginal tablets. It was pointed out earlier that NM is affected by light, especially UV light and storage temperature, and the potency of dry powder is reduced by 1 to 2% per month when stored at a temperature of 5 ° C or less. It has also been pointed out that NM powder is stable under freezing conditions but decomposes at elevated temperatures; its antibacterial activity can lose 75% within three hours at 100 ° C; humidity and pH also affect its stability. The authors found that the stability of the NM formulation is different from that of its powder and that the tablet has some protective effect; addition of tetracycline improves its antibacterial stability. This article investigated the stability of NM alone and in five different suppository bases at different temperatures. Experiment: Nystatin (USP Code); Bacteria