目的：研究罗库溴铵的预注效果。方法：ＡＳＡⅠ～Ⅱ级择期全麻手术４６例，男２５例，女２１例，分为三组。Ⅰ组（ｎ＝１８）用罗库溴铵预注法诱导插管，应用正交试验Ｌ（３７）方法，观察００４５、００６、００７５ｍｇ／ｋｇ三种不同水平的预注量（ＰＤ），２、３、４分钟预注时间（ＰＩ）及０３、０４５、０６ｍｇ／ｋｇ插管剂量（ＩＤ）对预注效果的影响；Ⅱ组（ｎ＝１８）用罗库溴铵０３、０４５、０６ｍｇ／ｋｇ常规诱导插管；Ⅲ组（ｎ＝１０）用琥珀胆碱１ｍｇ／ｋｇ诱导插管。结果：预注效果明显（Ｐ＜００５），ＩＤ和ＰＤ是决定起效时间的主要因素（Ｐ＜００５），ＰＩ不明显（Ｐ＝０４５）。结论：ＰＤ００６ｍｇ／ｋｇ、ＰＩ２分钟、ＩＤ０６ｍｇ／ｋｇ是罗库溴铵预注的较好模式。 Objective: To study the pre-injection effect of rocuronium. Methods: 46 cases of ASA Ⅰ ~ Ⅱ elective general anesthesia, 25 males and 21 females, were divided into three groups. Group Ⅰ (n = 18) was induced by rocuronium pre-injection. Orthogonal test L (37) was used to observe the different levels of 0045, 006, 0075 mg / kg (PD), pre-injection time (PI) of 2, 3 and 4 minutes and intubation dose of 03, 045 and 06 mg / kg ) Was induced by rocuronium 03, 045 and 06 mg / kg respectively. Group Ⅲ (n = 10) was induced by succinylcholine 1 mg / kg. Results: The pre-injection effect was significant (P <005). ID and PD were the main factors determining the onset time (P <005), while PI was not significant (P = 045). Conclusion: PD0  06mg / kg, PI2 minutes, ID0  6mg / kg is a better mode of pre-injection of rocuronium.