复习文献并报告４例莱姆病，其中３例主要侵犯神经系统。４例患者均未发现环形红斑，临床表现也各不相同，说明莱姆病侵犯全身多系统，神经系统的表现缺乏特异性。４例患者莱姆病抗体检查均超过诊断标准，其中１例血培养发现病原体。但临床也发现莱姆病抗体阳性最后确诊为其它疾病。提示应避免诊断扩大化 Literature review and report 4 cases of Lyme disease, of which 3 cases of major violations of the nervous system. None of the 4 patients had a ring-shaped erythema and their clinical manifestations were also different, indicating that Lyme disease invading the whole body and multiple systems lacks specificity in the performance of the nervous system. Four patients with Lyme disease antibody tests exceeded the diagnostic criteria, of which 1 case of blood culture found pathogens. But clinically also found that Lyme disease antibodies were finally diagnosed as other diseases. Tips to avoid the diagnosis of expansion