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作者对乳腺癌易感基因BRCA1、BRCA2 的定位、结构、功能以及这两个基因发生突变与遗传相关的乳腺癌和散发性乳腺癌之间的关系进行了文献综述 ,以期为乳腺癌的基础和临床研究提供新的方向。
The authors reviewed the relationship between the location, structure and function of breast cancer susceptibility genes BRCA1 and BRCA2 and the relationship between these two mutations and genetically related breast and sporadic breast cancer in order to provide a basis for breast cancer Clinical research provides a new direction.