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癫癎患者,尤其是难治性癫癎患者,发生猝死的风险较一般人群要高。癫癎猝死为癫癎患者突然发生非外伤、非溺死的死亡,并排除了癫癎持续状态,尸检未发现造成死亡的器质性或中毒性方面的确切原因。关于癫癎猝死机制的研究集中在癫癎发作可能导致的心律失常和呼吸抑制方面。文中对近年来在癫癎猝死机制中呼吸功能障碍、心脏功能障碍、意识障碍方面,以及分子和基因方面的研究进展进行综述。
Epilepsy patients, especially patients with refractory epilepsy, the risk of sudden death is higher than the general population. Sudden epileptic sudden epileptic patients with non-traumatic, non-drowning death, and ruled out the status of epileptic persistence, necropsy did not find the exact cause of death caused by organic or toxic. Research on the mechanism of sudden death in epilepsy has focused on arrhythmias and respiratory depression that may be caused by epileptic seizures. In this paper, in recent years, the mechanism of sudden death in epileptic sudden respiratory dysfunction, cardiac dysfunction, disturbance of consciousness, as well as the molecular and genetic advances are reviewed.