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表观遗传学是研究转录后与DNA结合的蛋白的修饰,而不是DNA序列的改变.心血管疾病是由环境因素和遗传因素相互作用引发的一种慢性疾病.近年来,越来越多的研究证实表观遗传因素参与了心血管疾病的发生发展,组蛋白修饰是表观遗传调控机制之一,其异常与心血管疾病发病关系密切.随着表观遗传学在心血管疾病中研究的进一步深入,表观遗传调节机制,尤其是组蛋白修饰在心血管系统疾病中的作用受到越来越多的关注,现总结并讨论国内外组蛋白修饰在心血管疾病中的研究进展.“,”The term epigenetic refers to the modification of post-translational protein binding with DNA,other than the change of DNA sequences.Cardiovascular disease(CVD) is a chronic disease that is caused by the interactions of environmental and genetic factors.Recently,the epigenetic has been identified to play a major role in the development of CVD.The histone modification is one of many mechanisms of epigenetic modification,and its abnormal modification is closely related with CVD.The mechanisms of epigenetic modulation are increasingly concerned with the development of its researches in CVD,especially histone modification.This paper summarized and discussed the progresses of histone modification in CVD in the world.