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在巨噬细胞刺激蛋白 (macrophagestimulatingprotein ,MSP)的刺激下 ,RON(macrophagestimulating 1receptor,MST1R)具有调节细胞扩散、转移、微管形成的功能 ,RON基因的激活与肿瘤发生有关。RON基因定位于 3p2 1.3,包含 2 0个外显子。成熟RON为 180kD的杂合双链二聚体。RON基因主要表达于人体上皮细胞、粒细胞、破骨细胞、单核细胞、巨核细胞以及扁桃体生发层、气管、皮肤、小肠、结肠、输卵管等器官。RON对NO的诱导合成有抑制作用 ;RON在神经、胚胎、呼吸的组织中也发挥一定的作用。RON分别与IL 3R、MET和整合素之间存在联合作用
The stimulation of macrophage stimulating protein (MSP), RON (macrophage stimulating ligand, MST1R) has the function of regulating cell proliferation, metastasis and microtubule formation, and the activation of RON gene is related to tumorigenesis. The RON gene is located at 3p2 1.3 and contains 20 exons. Mature RON is a 180 kD hybrid double-stranded dimer. RON gene is mainly expressed in human epithelial cells, granulocytes, osteoclasts, monocytes, megakaryocytes and tonsil germinal layers, trachea, skin, small intestine, colon, fallopian tubes and other organs. RON has an inhibitory effect on NO-induced synthesis; RON also plays a role in neural, embryonic, and respiration tissues. RON has a synergistic effect with IL 3R, MET and integrins, respectively