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子宫内膜容受性是妊娠建立的关键因素之一,在辅助生殖技术中,超生理水平的内分泌环境可能对子宫内膜容受性产生影响。子宫内膜厚度、内膜类型、子宫动脉及内膜下血流、子宫内膜胞饮突、外周血雌孕激素、白血病抑制因子(LIF)、基质金属蛋白酶(MMPs)、细胞黏附分子(CAMs)、Wnt信号转导系统、选择素、钙黏素、黏蛋白(MUC-1)、免疫球蛋白超家族(IG-SF)、血管内皮生长因子(VEGF)、肝素结合性表皮生长因子(HB-EGF)、集落刺激因子(CSF-1)、同源框基因(Hox基因)、骨桥蛋白、补体衰变加速因子、生长停滞和DNA损伤诱导蛋白、载脂蛋白D、Dickkopf/DKK1、单胺氧化酶A、白介素-15、促分裂活化蛋白激酶5、olfactomedin相关的雌激素受体位点蛋白。到目前为止,还没有一种分子标志物能成功地运用到临床作为子宫内膜容受性的标志。因此,寻找潜在的内膜容受性标志物的工作仍在继续进行。
Endometrial receptivity is one of the key factors in the establishment of pregnancy. In assisted reproductive technology, the physiological level of endocrine environment may have an impact on endometrial receptivity. Endometrial thickness, endometrial type, uterine artery and subintimal blood flow, endometriosis, peripheral progesterone, leukemia inhibitory factor (LIF), matrix metalloproteinases (MMPs), cell adhesion molecules ), Wnt signaling system, selectin, cadherin, MUC-1, IG-SF, VEGF, -EGF, CSF-1, Hox gene, osteopontin, complement decay accelerating factor, growth arrest and DNA damage-inducing protein, apolipoprotein D, Dickkopf / DKK1, monoamine oxidase A , Interleukin-15, mitogen-activated protein kinase 5, olfactomedin-related estrogen receptor site proteins. So far, no molecular marker has been successfully applied clinically as a marker of endometrial receptivity. Therefore, the search for potential markers of endometrial receptivity continues.